•Ancient times -
clinical observation
•1950-1960’s
- response to gluten free diet, 72-hr fecal
fat, low xylose test, origins of SB biopsy
•1970’s - Anti-gluten Ab
in blood / intestinal fluid
•1980’s - Antigliadin /
antiendomysial Ab in blood
•1990’s - Antitissue
transglutaminse Ab
• Mistakenly
thought to rule in and rule out all disease
•