Antigliadin Ab In the Intestine but not Blood with Mild Intestinal Damage
•Researchers assessed blood and aspirated small bowel fluid for antigliadin IgA antibody in:
–Celiacs; blood and SB aspirate was positive
–Normals; blood and SB aspirate was negative
–Celiacs after 1 yr on GFD; blood was negative, intestine was positive when mild SB inflammation persisted
•Used intestinal lavage and analysis of rectal effluent to test for the presence of intestinal antigliadin Ab
–Called “a relatively non-invasive screening method for early celiac sprue”
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O’Mahoney et al, Gut 1990