Early Diagnosis of Gluten Sensitivity using Fecal Testing

Studies of Gluten-Sensitivity without Villous Atrophy

•“Gluten-Sensitive Diarrhea” (Gastroenterology 1980;79:801)

–8 females, severe chronic diarrhea,normal blood and stool tests

•“Gluten-Sensitivity with Mild Enteropathy” (Gastro 1996;111:608)

–10 pts. diarrhea/steatorrhea, anemia, osteoporosis, mouth ulcers

–Small bowel biopsies reacted immunologically to gluten in vitro

•“Celiac-like Abnormalities in IBS patients” (Gastro 2001;121:1329)

–Small intestinal antigliadin IgA Ab, HLA-DQ2 in 30% of IBS pts

•“Celiac Disease without Villous Atrophy” (Dig Dis Sci 2001;46:879)

–10 pts. with abdominal symptoms, osteoporosis, (-* IEL’s

•All pts. became well on GFD; recurred with gluten