•Celiac sprue is the end-stage of
immunologic gluten sensitivity directed at the small
intestine
•HLA
genes (HLA-DQ2, DQ8) direct gluten-induced damage
to SB; other HLA/non-HLA genes damage skin (e.g. DH and/or other organs
•Blood tests/biopsies
can only diagnose celiac sprue
•GS with mild/no SB
damage; autoimmune disease of other organs;
relatives of celiacs are being missed