Celiac Sprue
Clinicopathologic Spectrum
•Clinical presentation
–Asymptomatic (with or without iron deficiency)
–Abdominal bloating, nausea, G-E reflux
–Diarrhea, weight loss, symptoms of fat malabsorption
•Histopathology
–Mild intraepithelial lymphocytosis or plasmacytosis of LP, normal villi and crypts   (May be read as normal)
–Partial or subtotal villous atrophy and inflammation
–Total villous atrophy, inflammation, crypt hyperplasia
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