•1950 -1960’s - response to gluten free diet, 72-hr                                    fecal fat, oral xylose test, origins of SB biopsy •1980 -1990’s - serologic testing for antigliadin Ab, antiendomysial Ab, antitissue transglutaminase Ab •2000’s - fecal testing for Antigliadin Ab and Antitissue transglutaminase Ab†; Quantitative fecal fat microscopy for malabsorption†; HLA-DQ typing