Research Supporting Non-Celiac
Gluten Sensitive Genes
•
DQ1,3 found more commonly in MC and RA
–
DQ3 subtypes are: DQ7, DQ8, DQ9
•
DQ1 found more commonly in gluten ataxia
•
DQ9 binds and reacts to gluten in vitro
•
Only DQ4 seems not to increase risk of GS
–
Rare in U.S. - 13% heterozygous, 0.4% homo.
–